Our research involves the application and development of theoretical methods for use on biological and organic molecular systems. Some current and recent project areas are briefly described below. If you have questions about any of them, send e-mail to me at jbriggs@uh.edu.

AIDS: HIV-1 Integrase structural studies and inhibitor design work.
Cancer: Computational work on anticancer microtubule stabilizing agents - Epothilones.
Cancer: Computational work on anticancer topoisomerase II poisons - Clerocidins (under construction).
Alanine racemase (under construction).
Mismatched electrostatics and molecular association. (under construction).
pKa studies.
UHBD development.
Cancer, Arthritis: zinc metalloproteases, and hydroxamic acids.
Chiral discrimination: cryptophanes for making chiral distinctions.